Nutritional and Safety Assessments of Foods and Feeds Nutritionally Improved through Biotechnology
Chassy B, Egnin M, Gao Y, Kleter GA, Nestel P, Newell-McGloughlin M, Phipps RH, Shillito R
Comprehensive Reviews in Food Science and Food Safety
January 1, 2004
Task Force #4
Comprehensive Reviews in Food Science and Food Safety. 2008;7(1):50-113
Abstract: The global demand for food is increasing because of the growing world population. At the same time, availability of arable land is shrinking. Traditional plant breeding methods have made and will continue to make important contributions toward meeting the need for more food. In many areas of the world, however, the problem is food quality. There may be enough energy available from food, but the staple foods lack certain essential nutrients. In the developed world, demand for “functional foods” (that is, foods that provide health benefits beyond basic nutrition) is increasing. Nutritional improvements in foods could help to meet both of these demands for improved food quality. Modern agricultural biotechnology, which involves the application of cellular and molecular techniques to transfer DNA that encodes a desired trait to food and feed crops, is proving to be a powerful complement to traditional methods to meet global food requirements. An important aspect of biotechnology is that it provides access to a broad array of traits that can help meet this need for nutritionally improved cultivars. The new varieties developed through modern biotechnology have been identified by a number of terms, including genetically modified (GM or GMO), genetically engineered (GE or GEO), transgenic, biotech, recombinant, and plants with novel traits (PNTs). For the present discussion, the term “GM” will be used because of its simplicity and broad public recognition.
To download this article, click here.
References
Chapter 1: An Introduction to Modern Agricultural Biotechnology
- ADSF 2002. Les plantes génétiquement modifiées. Rapport sur la science et la technologie nr13. Académie Des Sciences Française, Paris, France. Accessed 2003 Jul 22.
- Ahmed K. 2003. No risk in GM food, say doctors. The Observer Newspaper Sunday May 25 2003. Accessed 2003 May 25. LINK
- AMA. 1999. Biotechnology and the American Agricultural Industry. Policy Nr. H-480.985 of the American Medical Association, Chicago, IL. Available from: Accessed 2003 Jul 22. LINK
- Brent P, Bittisnich D, Brooke-Taylor S, Galway N, Graf L, Healy M, Kelly L. 2003. Regulation of genetically modified foods in Australia and New Zealand. Food Control 14: 409–16. LINK
- Brock RD. 1976. Prospects and perspectives in mutation breeding. Basic Life Sci. 8: 117–32. LINK
- CBAC. 2002. Annual Report of the Canadian Biotechnology Advisory Committee, Ottawa, Ontario, Canada. Accessed 2003 Jul 22. LINK
- Cockburn A. 2002. Assuring the safety of GM food. J. Biotechnol. 98: 79–106. LINK
- EU. 2001. EC-sponsored Research into on Safety of Genetically Modified Organisms; 5th Framework Program – External Advisory Groups. “GMO research in perspective.” Report of a workshop held by External Advisory Groups of the “Quality of Life and Management of Living Resources” Program. Accessed 2003 Jul 22.
- FAO/WHO. 1996. Biotechnology and food safety. Report of a joint FAO/WHO consultation; 30 Sept. – 4 Oct. 1996. FAO Food and Nutrition Paper 61. Rome, Italy: Food and Agriculture Organization of the United Nations. Accessed 2003 Jul 22. LINK
- FAO/WHO. 2000. Safety Aspects of Genetically Modified Foods of Plant Origin. Report of a Joint FAO/WHO Expert Consultation on Foods Derived from Biotechnology, 29 May – 2 June 2000. Rome, Italy: Food and Agriculture Organization of the United Nations. Accessed July 22. LINK
- FAO/WHO. 2002. Report of the third session of the Codex Ad Hoc Intergovernmental Task Force on Foods Derived from Biotechnology (ALINORM 01/34). Rome, Italy: Codex Ad Hoc Intergovernmental Task Force on Foods Derived from Biotechnology, Food and Agriculture Organization of the United Nations. Available from: LINK. Accessed 2003 Jul 22.
- FDA. 1992. Statement of Policy: Foods Derived From New Plant Varieties, Federal Register, Volume 57, Number 104. Available from: LINK. Accessed 2003 Jul 22.
- Gianessi, L. P, C. S. Silvers, S. Sankula, and J. E. Carpenter. 2002. Executive summary – Plant biotechnology – Current and potential impact for improving pest management in US agriculture. An analysis of 40 case studies. 1–23. NCFAP. Washington, D.C.: National Center for Food and Agricultural Policy Available from: LINK. Accessed 2003 Jul 22.
- Hollingsworth RM, Bjeldanes LF, Bolger M, Kimber I, Meade BJ, Taylor SL, Wallace KB. 2003. The safety of genetically modified foods produced through biotechnology. Report of the Society of Toxicology. Toxicol Sci 71: 2–8. LINK
- ICSTI. 2002. Report on biotechnology. Dublin, Ireland: Irish Council for Science, Technology and Innovation. Available from: LINK. Accessed 2003 Jul 22.
- IFBIC. 1990. Biotechnologies and food: Assuring the safety of foods produced by genetic modification. Regul Toxicol Pharmacol 12: S1–S196. LINK
- ILSI. 1997. Europe Novel Foods Task Force. The safety assessment of novel foods. Food Chem Toxicol 34: 931–40. LINK
- ILSI. 2003. Crop composition database. Available from: LINK. Accessed 2003 Oct 13.
- International Field Test Sources. 2002. Field Test Releases in the U.S. Blacksburg, Va.: Information Systems for Biotechnology. Available from: LINK. Accessed 2003 Jul 22.
- James C. 2002. Global Review of Commercialized Transgenic Crops: 2001. ISAAA Briefs No. 26. Ithaca, N.Y.: International Service for the Acquisition of Agri-biotech Applications. Available from: LINK. Accessed 2003 Jul 22.
- James C. 2003. Preview: Global Status of Commercialized Transgenic Crops: 2003. ISAAA Briefs Nr 30. Ithaca, N.Y.: International Service for the Acquisition of Agribiotech Applications. Available from: LINK. Accessed 2004 Feb 17.
- Klann EM, Chetelat RT, Bennett AB. 1993. Expression of acid invertase gene controls sugar composition in tomato (Lycopersicon) fruit. Plant Physiol 103: 863–70. LINK
- Klann EM, Hall B, Bennett AB. 1996. Antisense acid invertase (TIV1) gene alters soluble sugar composition and size in transgenic tomato fruit. Plant Physiol 112: 1321–30. LINK
- Kuiper HA, Kleter GA, Noteborn HPJM, Kok EJ. 2001. Assessment of the food safety issues related to genetically modified foods. Plant J 27: 503–28. Accessed 2003 Jul 22. LINK
- Metcalfe DD, Astwood JD, Townsend R, Sampson HA, Taylor SL, Fuchs RL. 1996. Assessment of allergenic potential of foods derived from genetically engineered crop plants. Crit Rev Food Sci Nutr 36: S165–86. LINK
- Munkvold GP, Hellmich RL, Rice LG. 1999. Comparison of fumonisin concentrations in kernels of transgenic Bt maize hybrids and nontransgenic hybrids. Plant Dis 83: 130–8. LINK
- NRC. 2000. Report on “Genetically Modified Pest-Protected Plants: Science and Regulation” Washington, D.C.: National Academy of Sciences. Available from: LINK. Accessed 2003 Jul 22.
- NZRC. 2001. Report of the Royal Commission on Genetic Modification. New Zealand Royal Commission on Genetic Modification. Available from: LINK. Accessed 2003 Nov 24.
- OECD. 1993. Safety Evaluation of Foods Derived by Modern Biotechnology: Concepts and Principles. Paris, France: Organization for Economic Co-Operation and Development. LINK
- Robinson C. 2001. ILSI Europe concise monograph series genetic modification technology and food consumer health and safety. 45s. LINK
- Rowe RC, Farley JD. 1981. Control of botrytis stem canker in greenhouse tomatoes. In: Greenhouse Vegetable Crops–1981: A Summary of Research. Res. Circ. 264. Wooster, Ohio: OARDC. p 1515.
- Royal Society. 2002. Genetically modified plants for food use and human health–an update. London, U.K.: The Royal Society. Available from: Accessed 2003 Jul 22. LINK.
- Royal Society. 2003. GM crops, modern agriculture and the environment. Report of a Royal Society Discussion Meeting held on 11 February 2003. London, U.K.: The Royal Society. Available from: LINK. Accessed 2003 Jul 22.
Chapter 2: Improved Nutritional Quality through Modern Biotechnology
- AIFCR American Institute for Cancer Research. 1997. Food, nutrition and the prevention of cancer: a global perspective. Washington, D.C.: World Cancer Research Fund, American Institute for Cancer Research. 670 p.
- Allen SM, Caimi PG, Stoop JM. 2002. Fructan biosynthetic enzymes. EI Dupont De Nemours and Co. U.S. Patent Application 20020170086.
- Anti M, Armelao F, Marra G, Percesepe A, Bartoli GM, Palozza P, Parrella P, Canetta C, Gentiloni N, De Vitis I. 1994. Effects of different doses of fish oil on rectal cell proliferation in patients with sporadic colonic adenomas. Gastroenterology 107: 170917–8. LINK
- Austin-Phillips S, Bingham ET, Koegel RG, Rausch J, Straub RJ, Will J, Zeigelhoffer T, Zeigellhoffer P, Burgess RR. 1999. Production of industrial and animal feed enzymes in transgenic alfalfa. Available from: LINK. Accessed 2003 Jul. 24.
- Baba N, Bracco EF, Hashim SA. 1982. Enhanced thermogenesis and diminished deposition of fat in response to overfeeding with diet containing medium chain triglyceride. Am J Clin Nutr 35: 678–82. LINK
- Bacon JR, Williamson G, Garner RC, Lappin G, Langouet S, Bao Y. 2003. Sulforaphane and quercetin modulate PhIP-DNA adduct formation in human HepG2 cells and hepatocytes. Carcinogenesis 24: 1903–11. LINK
- Bao YP, Bacon J, Williamson G. 2001. Effect of phytochemicals on PhIP-DNA adduct formation in human Hep G2 and hepatocytes. In: PfannhauserW, FenwickGR, KnokharS, editor. Biologically-active phytochemicals in food: Analysis, metabolism, bioavailability and function. London, U.K.: Royal Society of Chemistry. p 589–91.
- Barro F, Rooke L, Bekes F, Gras P, Tatham AS, Fido R, Lazzeri PA, Shewry PR, Barcelo P. 1997. Transformation of wheat with high molecular weight subunit genes results in improved functional properties. Nat Biotechnol 15: 1295–9. LINK
- Beauregard M, Dupont C, Hefford MA. 1995. Design, expression and initial characterization of MB1, a de novoprotein enriched in essential amino acids. Biotechnology 13: 974–81. LINK
- Block G, Patterson B, Subar A. 1992. Fruit, vegetables, and cancer prevention: A review of the epidemiological evidence. Nutr Canc 18: 1–29. LINK
- Bouhnik Y, Vahedi K, Achour L, Attar A, Salfati J, Pochart P, Marteau P, Flourie B, Bornet F, Rambaud JC. 1999. Short-chain fructo-oligosaccharide administration dose-dependently increases fecal bifidobacteria in healthy humans. J Nutr 129: 113–6. LINK
- Brinch-Pedersen H, Galili G, Knudsen S, Holm PB. 1996. Lysine modification in Zea Mays. Plant Mol Biol 32: 611–20. LINK
- Broughton KS, Johnson CS, Pace BK, Liebman M, Kleppinger KM. 1997. Reduced asthma symptoms with n-3 fatty acid ingestion are related to 5-series leukotriene production. Am J Clin Nutr 65: 1011–7. LINK
- Bruce W, Folkerts O, Garnaat C, Crasta O, Roth B, Bowen B. 2000. Expression profiling of the maize flavonoid pathway genes controlled by estradiol-inducible transcription factors CRC and P. Plant Cell 12: 65–80. LINK
- Buchanan BB, Adamidi C, Lozano RM, Yee BC, Momma M, Kobrehel K, Ermel R, Frick OL. 1997. Thioredoxin-linked mitigation of allergic responses to wheat. Proc Nat Acad Sci USA 94: 5372–7. LINK
- Buchanan BB, Gruissen W, Jones RL. 2000. Biochemistry & Molecular Biology of Plants. Rockville, Md.: American Society of Plant Physiologists. 1367 p.
- Buhr T, Sato S, Ebrahim F, Xing A, Zhou Y, Mathiesen M, Schweiger B, Kinney A, Staswick P, Clemente P. 2002. Ribozome termination of RNA transcripts down-regulate seed fatty acid genes in transgenic soybean. Plant J 30: 155–63. LINK
- Carlson SE. 1999. Long-chain polyunsaturated fatty acids and development of human infants. Acta Pediatr Suppl 88(430): 72–7. LINK
- Chakraborty S, Chakraborty N, Datta A. 2000. Increased nutritive value of transgenic potato by expressing a nonallergenic seed albumin gene from Amaranthus hypochondriacus. Proc Natl Acad Sci USA 97: 3724–9. LINK
- Chapman KD, Austin-Brown S, Sparace SA, Kinney AJ, Ripp KG, Pirtle IL, Pirtle RM. 2001. Transgenic cotton plants with increased seed oleic acid content. J Am Oil Chem Soc 78: 941–7. LINK
- Chen Z, Young TE, Ling J, Chang SC, Gallie DR. 2003. Increasing vitamin C content of plants through enhanced ascorbate recycling. Proc Nat Acad Sci USA 100: 3525–30. LINK
- Christensen JH, Christensen MS, Dyerberg J, Schmidt EB. 1999. Heart rate variability and fatty acid content of blood cell membranes: a dose-response study with n-3 fatty acids. Am J Clin Nutr 70: 331–7. LINK
- Codding PW. 1983. Structural studies of sodium channel neurotoxins. 3. Crystal structures and absolute configuration of grayanotoxin III and alpha-dihydrograyanotoxin II. J Am Chem Soc 106: 7905–9. LINK
- Conn EE. 1995. The world of phytochemicals. In: GustineDL, FloresHE, editor. Phytochemicals and Health (Vol. 15). Rockville, Md.: American Society of Plant Physiologists. p 1–14.
- Datta K, Baisakh N, Oliva N, Torrizo L, Abrigo E, Tan J, Rai M, Rehana S, Al-Babili S, Beyer P, Potrykus I, Datta SK. 2003. Bioengineered ‘golden’ indica rice cultivars with beta-carotene metabolism in the endosperm with hygromycin and mannose selection systems. Plant Biotechnol J 1: 81–90. LINK
- Dehesh K, Jones A, Knutzon DS, Voelker TA. 1996. Production of high levels of 8: 0 and 10: 0 fatty acids in transgenic canola by overexpression of Ch FatB2, a thioesterase cDNA from Cuphea hookeriana. Plant J 9: 167–72. LINK
- DellaPenna D. 1999. Nutritional genomics: manipulating plant micronutrients to improve human health. Science 285: 375–9. LINK
- Del Vecchio AJ. 1996. High laurate canola. How Calgene’s program began, where it’s headed. INFORM International News on Fats, Oils and Related Materials 7: 230.
- Dinkins RD, Reddy MSS, Meurer CA, Yan B, Trick H, Thibaud-Nissen F, Finer JJ, Parrott WA, Collins GB. 2001. Increased sulfur amino acids in soybean plants overexpressing the maize 15 kDa zein protein. In Vitro Cell Dev Biol Plant 37: 742–7. LINK
- Dry J, Vincent D. 1991. Effect of a fish oil diet on asthma: results of a 1-year double-blind study. Int Arch Allergy Appl Immunol 95: 156–7. LINK
- Duvick J. 2001. Prospects for reducing fumonisin contamination of maize through genetic modification. Environ. Health Perspect. 109: 337–42. LINK
- Falco S, Guida T, Locke M, Mauvais J, Saunders C, Ward T, Weber P. 1995. Transgenic canola and soybean seeds with increased lysine. Bio/Technology 13: 577–82. LINK
- Fortin PR, Lew RA, Liang MH, Wright EA, Beckett LA, Chalmers TC, Sperling RI. 1995. Validation of a meta-analysis: the effects of fish oil in rheumatoid arthritis. J Clin Epidemiol 48: 1379–90. LINK
- Frankel EN, Waterhouse AL, Kinsella JE. 1993. Inhibition of human LDL oxidation by resveratrol. Lancet 341: 1103–4. LINK
- Fraser PD, Romer S, Kiano JW, Shipton CA, Mills PB, Drake R, Schuch W, Bramley PM. 2001. Elevation of carotenoids in tomato by genetic manipulation. J Sci Food Agric 81: 822–7. LINK
- Friedman M, Rayburn JR, Bantle JA. 1991. Developmental toxicology of potato alkaloids in the frog embryo teratogenesis assay–Xenopus (FETAX). Food Chem Toxicol 29: 537–47. LINK
- Friedrich L, Vernooij B, Gaffney T, Morse A, Ryals J. 1995. Characterization of tobacco plants expressing a bacterial salicylate hydroxylase gene. Plant Mol Biol 29: 959–68. LINK
- Fushiki T, Matsumoto K, Inoue K, Kawada T, Sugimoto E. 1995. Swimming endurance capacity of mice is increased by chronic consumption of medium-chain triglycerides. J Nutr 125: 531–9. LINK
- Geliebter A, Torbay N, Bracco EF, Hashim SA, Van Itallie TB. 1983. Overfeeding with medium-chain triglyceride diet results in diminished deposition of fat. Am J Clin Nutr 37: 1–4. LINK
- Gerhauser C, You M, Liu JF, Moriarty RM, Hawthorne M, Mehta RG, Moon RC, Pez-zuto JM. 1997. Cancer chemopreventive potential of sulforamate, a novel analogue of sulforaphane that induces phase 2 drug-metabolizing enzymes. Canc Res 57: 272–8. LINK
- Gianessi LP, Silvers CS, Sankula S, Carpenter JE. 2002. Executives summary – Plant biotechnology – Current and potential impact for improving pest management in US agriculture. An Analysis of 40 Case Studies. 1–23. NCFAP National Center for Food and Agricultural Policy, Washington, DC . Available from: LINK. Accessed 2003 Jul 22. LINK
- Giovannucci E. 2002. A review of epidemiologic studies of tomatoes, lycopene, and prostate cancer. Exp Biol Med 227: 852–9. LINK
- Gogos CA, Ginopoulos P, Salsa B, Apostolidou E, Zoumbos NC, Kalfarentzos F. 1998. Dietary omega-3 polyunsaturated fatty acids plus vitamin E restore immu-nodeficiency and prolong survival for severely ill patients with generalized malignancy. Cancer 82: 395–402. 3.0.CO;2-1/abstract”LINK
- Goldberg I. 1994. Functional foods, designer foods, pharmafoods, nutraceuticals. New York, N.Y.: Chapman & Hall. 571 p.
- Goto F, Yoshihara T, Shigemoto N, Toki S, Takaiwa F. 1999. Iron fortification of rice seed by the soybean ferritin gene. Nat Biotechnol 17: 282–6. LINK
- Griga M, Kosturkova G, Kuchuk N, Ilieva-Stoilova M. 2001. Biotechnology. In: HedleyCL, editor. Carbohydrates in grain legume seeds. Improving nutritional quality and agronomic characteristics. Wallingford, U.K.: CAB International. p 145–207.
- Guo D, Chen F, Wheeler J, Winder J, Selman S, Peterson M, Dixon RA. 2001. Improvement of in-rumen digestibility of alfalfa forage by genetic manipulation of lignin O-methyltransferases. Transgen Res 10: 457–64. LINK
- Haake V, Zrenner R, Sonnewald U, Stitt M. 1998. A moderate decrease of plastid aldolase activity inhibits photosynthesis, alters the levels of sugars and starch, and inhibits growth of potato plants. Plant J 14: 147–57. LINK
- Hajirezaei M, Sonnewald U, Viola R, Carlisle S, Dennis DT, Stitt M. 1994. Transgenic potato plants with strongly decreased expression of pyrophosphate: fructose-6-phosphate phosphotransferase show no visible phenotype and only minor changes in metabolic fluxes in their tubers. Planta 192: 16–30. LINK
- Hall AH, Rumack BH. 1986. Clinical toxicology of cyanide. Ann Emerg Med 15: 1067–74. LINK
- Harper AF, Kornegay ET, Schell TC. 1997. Phytase supplementation of low-phosphorus growing-finishing pig diets improves performance, phosphorus digestibility, and bone mineralization and reduces phosphorus excretion. J Anim Sci 75: 3174–86. LINK
- Hartwig EE, Kuo TM, Kenty MM. 1997. Seed protein and its relationship to soluble sugars in soybeans. Crop Sci 37: 770–3. LINK
- Hellwege EM, Czapla S, Jahnke A, Willmitzer L, Heyer AG. 2000. Transgenic potato (Solanum tuberosum) tubers synthesize the full spectrum of inulin molecules naturally occurring in globe artichoke (Cynara scolymus) roots. Proc Nat Acad Sci USA 97: 8699–704. LINK
- Helm RM, Cockrell G, Connaughton C, West CM, Herman E, Sampson HA, Bannon GA, Burks AW. 2000. Mutational analysis of the IgE-binding epitopes of P34/Gly m Bd 30K. J Allergy Clin Immunol 105: 378–84. LINK
- Herman E. 2002. Targeted gene silencing removes an immunodominant allergen from soybean seeds. Agricultural Research Magazine, September 2002 50(9). LINK
- Herman EM, Helm RM, Jung R, Kinney AJ. 2003. Genetic modification removes an immunodominant allergen from soybean. Plant Physiol 132: 36–43. LINK
- Hipskind JD, Paiva NL. 2000. Constitutive accumulation of a resveratrol-glucoside in transgenic alfalfa increases resistance to Phoma medicaginis. Mol Plant-Microbe Interact 13: 551–62. LINK
- IFIC. 2002. Background on Functional Foods. International Food Information Council, Washington, DC . Available from: LINK. Accessed 2003 Jul 24.
- Isolauri E, Ribeiro HC, Gibson G, Saavedra J, Saliminen S, Vanderhoof J, Varavithya W. 2002. Functional foods and probiotics: Working Group Report of the First World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr 35(Suppl 2): S106–9. LINK
- James MJ, Ursin V, Cleland LG. 2003. Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids Am J Clin Nutr 77: 1140–5. LINK
- Jang M, Cai L, Udeani G, Slowing K, Thomas C, Beecher C, Fong H, Farnsworth N, Kinghorn D, Mehta R, Moon R. M. Pezzuto J. 1997. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275: 218–20. LINK
- Jung W, Yu O, Lau SC, O’Keefe DP, Odell J, Fader G, McGonigle B. 2000. Identification and expression of isoflavone synthase, the key enzyme for biosynthesis of isoflavones in legumes. Nat. Biotechnol. 18: 208–12. LINK
- Kaiser J. 2000. Plant Genetics: from genome to functional genomics. Science 288: 1715. LINK
- Katz DP, Manner T, Furst P, Askanazi J. 1996. The use of an intravenous fish oil emulsion enriched with omega-3 fatty acids in patients with cystic fibrosis. Nutrition 12: 334–9. LINK
- Kay AB. 1997. Concepts of allergy and hypersensitivity. In: Allergy and Allergic Diseases. A. B.Kay ed., Blackwell Sciences, London, U.K. p 23–35.
- Kehrer JP, Smith CV. 1994. Free radicals in biology: sources, reactivities, and roles in the etiology of human diseases. In: FreiB, editor. Natural Antioxidants in Human Health and Diseases. Vol. 2. New York, N.Y.: Academic Press. p 25–62.
- Kerr PS, Pearlstein RW, Schweiger BJ, Becker-Manley MF, Pierce JW. 1998. Nucleotide sequences of galactinol synthase from zucchini and soybean. U.S. Patent Application No. 5773699, June 30 1998.
- Keshavarz K. 2003. The effect of different levels of nonphytate phosphorus with and without phytase on the performance of four strains of laying hens. Poult Sci 82: 71–91. LINK
- Kinney AJ. 1998. Manipulating flux through plant metabolic pathways. Curr Opin Plant Biol 1: 173–8. LINK
- Kinney AJ, Knowlton S. 1998. Designer oils: the high oleic acid soybean. In: RollerandS, HarlanderS, editor. Genetic Modification in the Food Industry. London, U.K.: Blackie. p 193–213.
- Kramer KJ, Morgan TD, Throne JE, Dowell FE, Bailey M, Howard JA. 2000. Transgenic avidin maize is resistant to storage insect pests. Nat Biotechnol 18: 670–4. LINK
- Krishnamurty K, Giroux MJ. 2001. Expression of wheat puroindoline genes in transgenic rice enhances grain softness. Nat Biotechnol 19: 162–6. LINK
- Lachance PA. 1998. Overview of key nutrients: micronutrient aspects. Nutr Rev 56(4 Pt 2): S34–9. LINK
- Lai J, Messing J. 2002. Increasing maize seed methionine by mRNA stability. Plant J 30: 395–402. LINK
- Landmark K, Abdelnoor M, Urdal P, Kilhovd B, Dorum HP, Borge N, Refvem H. 1998. Use of fish oils appears to reduce infarct size as estimated from peak creatine kinase and lactate dehydrogenase activities. Cardiology 89: 94–102. LINK
- Liu Q, Singh S, Green A. 2002. High-oleic and high-stearic cottonseed oils: nutritionally improved cooking oils developed using gene silencing. J Am Coll Nutr 21: 205S–11S. LINK
- Lucca P, Hurrell R, Potrykus I. 2002. Fighting iron deficiency anemia with iron-rich rice. J Am Coll Nutr 21: 184S–90S. LINK
- Marsic V, Yodice R, Orthoefer F. 1992. The dietary role of monounsaturates. INFORM 3: 681–6.
- Mazur B, Krebbers E, Tingey S. 1999. Gene discovery and product development for grain quality traits. Science 285: 372–5. LINK
- McCaslin M. 2001. Genetic Engineering in Alfalfa, U.S. Dairy Forage Research Center. 20th Anniversary Meeting. Available from: LINK. Accessed 2003 Oct 16.
- McCue KF, Shepherd LVT, Allen PV, Maccree MM, Rockhold DR, Davies HV, Belknap WR. 2003. Modification of steroidal alkaloid biosynthesis in transgenic tubers containing an antisense sterol glyco transferase (Sgt) gene encoding a novel steroidal alkaloid diglycoside rhamnosyl transferase. Paper presented at the 87th Annual Meeting of The Potato Association of America; August 10–14 2003; Spokane, Wash.
- McDonald BE. 1995. Oil properties of importance in human nutrition. In: D. S.Kimber DS, McGregorDI, editor. Brassica oilseeds – Production and utilization. Wallingford, U.K.: CAB. p 291–9.
- Mehta RA, Cassol T, Li N, Ali N, Handa AK, Mattoo AK. 2002. Engineered polyamine accumulation in tomato enhances phytonutrient content, juice quality, and vine life. Nat Biotechnol 20: 613–8. LINK
- Moffatt MEK, Longstaffe S, Besant J, Dureski C. 1994. Prevention of iron deficiency and psychomotor decline in high risk infants through use of iron-fortified infant formula: a randomized clinical trial. J. Pediatr. 125: 527–34. LINK
- Moisyadi S, Neupane KR, Stiles JI. 1998. Cloning and characterization of a cDNA encoding xanthosine-N7-methyltransferase from coffee (Carica papaya L.). Acta Hortic 461: 367–77. LINK
- Muir SR, Collins GJ, Robinson S, Hughes S, Bovy A, De Vos CHR, Van Tunen AJ, Verhoeyen ME. 2001. Overexpression of petunia chalcone isomerase in tomato results in fruit containing increased levels of flavonols. Nat Biotechnol 19: 470–4. LINK
- Napoli C, Lemieux C, Jorgensen R. 1990. Introduction of a chimeric chalcone synthase gene into Petunia results in reversible co-suppression of homologous genes in trans. Plant Cell 2: 279–89. LINK
- Norrish AE, Skeaff CM, Arribas GL, Sharpe SJ, Jackson RT. 1999. Prostate cancer risk and consumption of fish oils: a dietary biomarker- based case-control study. Br J Canc 81: 1238–42. LINK
- North Carolina Cooperative Extension Service. 2000. Genetically modified organisms in animal production. Raleigh, N.C. Swine News 23(5): 1–2.
- Ohta A, Motohashi Y, Sakai K, Hirayama M, Adachi T, Sakuma K. 1998. Dietary fructo-oligasaccharides increase calcium absorption and levels of mucosal calbindin-D9K in the large intestine of gastrectomized rats. Scand J Gastroenterol 33: 1062–8. LINK
- O’Quinn P, Nelssen J, Goodband R, Knabe D, Woodworth J, Tokach M, Lohrmann T. 2000. Nutritional value of a genetically improved high-lysine, high-oil corn for young pigs. J Anim Sci 78: 2144–9. LINK
- Pace-Asciak CR, Hahn S, Diamandis EP, Soleas G, Goldberg DM. 1995. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta 235: 207–19. LINK
- Paul MJ, Knight JS, Habash D, Parry MAJ, Lawlor DW, Barnes SA, Loynes A, Gray JC. 1995. Reduction in phosphoribulokinase activity by antisense RNA in transgenic tobacco: Effect on assimilation and growth in low irradiance. Plant J CO2 7: 535–42. LINK
- Pierre F, Perrin P, Champ M, Bornet F, Meflah K, Menanteau J. 1997. Short-chain fructo-oligosaccharides reduce the occurrence of colon tumors and develop gut-associated lymphoid tissue in Min mice. Canc Res 57: 225–8. LINK
- Pietinen P, Rimm EB, Korhonen P, Hartman AM, Willett WC, Albanes D, Virtamo J. 1996. Intake of dietary fiber and risk of coronary heart disease in a cohort of Finnish men. The alpha-tocopherol beta-carotene cancer prevention study. Circulation 94: 2720–7. LINK
- Potrykus I. 1999. Vitamin-A and iron-enriched rices may hold key to combating blindness and malnutrition: a biotechnology advance. Nat Biotechnol 17: 37. LINK
- Prakash CS, Egnin M, Jaynes J. 2000. Increasing the protein content in sweet potato using a synthetic storage protein gene. In: Abstracts of Papers, American Chemical Society. Chicago, Ill.: ACS. 219(1–2): AGFD69.
- Pusztai A, Grant G, Palmer R. 1975. Nutritional evaluation of kidney beans (Phaseolus vulgaris): the isolation and partial characterisation of toxic constituents. J. Sci. Food Agric 26: 149–56. LINK
- Rapp W. 2002. Development of soybeans with improved amino acid composition. 93rd AOCS Annual Meeting & Expo; May 5–8; Montréal, Québec, Canada . Champaign, Ill.: American Oil Chemists’ Society Press. p 79–86.
- Rickard SE, Thompson LU. 1997. Phytoestrogens and lignans: Effects on reproduction and chronic diseases. In: ShahidiF, editor. Antinutrients and phytochemicals in food. Washington, D.C.: American Chemical Society. p 273–93. LINK
- Richardson PH, Jeffcoat R, Shi Y-C. 2000. High-amylose starches: From biosynthesis to their use as food. MRS Bulletin, Dec. 2000. Warrendale, Pa.: Material Research Society. p 20–4. Available from: LINK. Accessed 2003 Oct 17.
- Risley CR, Lohrmann TT. 1998. Growth performance and apparent digestibility of weanling pigs fed diets containing low stachyose soybean meal. J Anim Sci 76(Suppl. 1): 179 (Abstract).
- Roberfroid MB, Delzenne NM. 1998. Dietary fructans. Annu Rev Nutr 18: 117–43. LINK
- Rooke L, Békés F, Fido R, Barro F, Gras P, Tatham AS, Barcelo P, Lazzeri PA, Shewry PR. 1999. Overexpression of a gluten protein in transgenic wheat results in highly elastic dough. J. Cereal Sci. 30: 115–20. LINK
- Rosati C, Aquilani R, Dharmapuri S, Pallara P, Marusic C, Tavazza R, Bouvier F, Camara B, Giuliano G. 2000. Metabolic engineering of beta-carotene and lycopene content in tomato fruit. Plant J 24: 413–9. LINK
- Sahaafsma G, Meuling WJ, Van Dokkum W, Bouley C. 1998. Effects of a milk product, fermented by Lactobaccillus acidophilus and with fructo-oligosaccharides added, on blood lipids in male volunteers. Eur J Clin Nutr 52: 436–40. LINK
- Schwall GP, Safford R, Westcott RJ, Jeffcoat R, Tayal A, Shi YC, Gidley MJ, Jobling SA. 2000. Production of very-high-amylose potato starch by inhibition of SBE A and B. Nat Biotechnol 18: 551–4. LINK
- Seshadri S, Gopaldas T. 1989. Impact of iron supplementation on cognitive functions in preschool and school aged children: the Indian experience. Am J Clin Nutr 50: 675–86. LINK
- Sévenier R, Hall RD, Van Der Meer IM, Hakkert HJC, Van Tunen AJ, Koops AJ. 1998. High level fructan accumulation in a transgenic sugar beet. Nat Biotechnol 16: 843–6. LINK
- Shintani D, DellaPenna D. 1998. Elevating the vitamin E content of plants through metabolic engineering. Science 282: 2098–100. LINK
- Simmonds DH, Donaldson PA. 2000. Genotype screening for proliferative embryogenesis and biolistic transformation of short-season soybean genotypes. Plant Cell Rep 19: 485–90. LINK
- Simonsen N, Van’t Veer P, Strain JJ, Martin-Moreno JM, Huttunen JK, Navajas JF, Martin BC, Thamm M, Kardinaal AF, Kok FJ, Kohlmeier L. 1994. Adipose tissue omega-3 and omega-6 fatty acid content and breast cancer in the EURAMIC Study. Am J Epidemiol 147: 342–52. LINK
- Siritunga D, Sayre RT. 2003. Generation of cyanogen-free transgenic cassava. Planta 217: 367–73. LINK
- Smeekens S. 1997. Engineering plant metabolism. Trends Plant Sci 2: 286–8. LINK
- Smith JG, Yokoyama WH, German JB. 1998. Butyric acid from the diet: actions at the level of gene expression. Crit Rev Food Sci Nutr 8: 259–97. LINK
- Smuts CM, Huang M, Mundy D, Plasse T, Major S, Carlson SE. 2003. A randomized trial of docosahexaenoic acid supplementation during the third trimester of pregnancy. Obstet Gynecol 101: 469–79. LINK
- Stark DM, Timmerman KP, Barry GF, Preiss J, Kishore GM. 1992. Role of the amount of starch in plant tissue by ADP glucose pyrophosphorylase. Science 258: 287–92. LINK
- Steinmetz KA, Potter JD. 1996. Vegetables, fruit, and cancer prevention: a review. J Am Diet Assoc 96: 1027–39. LINK
- Stoll A, Severus E, Freeman MP, Rueter S, Zboyan H, Diamond E, Cress KK, Marangell LB. 1999. Omega 3 fatty acids in biopolar disorder. Arch Gen Psych 56: 407–12. LINK
- Stringer RE, Hart CA, Edwards SW. 1996. Sodium butyrate delays neutrophil apoptosis: role of protein biosynthesis in neutrophil survival. Br J Hematol 92: 169–75. LINK
- Suarez FL, Springfield J, Furne JK, Lohrmann TT, Kerr PS, Levitt MD. 1999. Gas production in humans ingesting a soybean flour derived from beans naturally low in oligosaccarides. Am J Clin Nutr 69: 135–9. LINK
- Tada Y, Nakase M, Adachi T, Nakamura R, Shimada H, Takahashi M, Fujimura T, Matsuda T. 1996. Reduction of 14–16 kDa allergenic proteins in transgenic rice plants by antisense gene. FEBS Lett 391: 341–5. LINK
- Taylor SL, Hefle SL. 2001. Allergic reactions and food intolerances. In: KotsonisFN, MackeyM, editor. Nutritional Toxicology (2nd Ed.). New York: Taylor & Francis. p 93.
- Taylor SL, Hefle SL, Gauger BA. 2000. Food allergies and sensitivities. In: HelferichW, WinterC, editor. Toxicology of Food. Boca Raton, Fla.: CRC Press. p 1–36.
- Tropf S, Lanz T, Rensing S, Schröder J, Schröder G. 1994. Evidence that stilbene synthases have developed from chalcone synthases several times in the course of evolution. J Mol Evol 38: 610–8. LINK
- UPI. 2002. Wheat Inhibits Colon Cancer. Washington, D.C.: United Press International. LINK
- Ursin V. 2000. Genetic modification of oils for improved health benefits. Presentation at conference, Dietary Fatty Acids and Cardiovascular Health: Dietary Recommendations for Fatty Acids: Is There Ample Evidence? June 5–6, 2000. Reston Va.: American Heart Association.
- Van Heugten E. 2001. Mycotoxins and other antinutritional factors in swine feeds. In: LewisAJ, SouthernLL, editor. Swine Nutrition (2nd Ed.). Boca Raton, Fla.: CRC Press. p 574–5.
- Vasconcelos M, Datta K, Oliva N, Khalekuzzaman M, Torrizo L, Krishnan S, Oliveira M, Goto F, Datta SK. 2003. Enhanced iron and zinc accumulation in trangenic rice with the ferritin gene. Plant Sci 164: 371–8. LINK
- Vermerris W, Bout S. 2003. Molecular Genetics and Genomics online. Available from: LINK. Accessed 2003 Jul 24.
- Viveros A, Brenes A, Arija I, Centeno C. 2002. Effects of microbial phytase supplementation on mineral utilization and serum enzyme activities in broiler chicks fed different levels of phosphorus. Poult. Sci. 81: 1172–83. LINK
- Wang X, Gibson GR. 1993. Effects of the in vitro fermentation of oligofructose and inulin by bacteria growing in the human large intestine. J Appl Bacteriol 75: 373–80. LINK
- Watkins SM, Carter LC, Mak J, Tsau J, Yamamoto S, German JB. 1999. Butyric acid and tributyrin induce apoptosis in human hepatic tumour cells. J Dairy Res 66: 559–67. LINK
- Watkins SM, German JB. 1998. Omega fatty acids. In: AkohCC, MinDB, editor. Food Lipids: Chemistry, Nutrition and Biotechnology. Marcel Dekker, New York . p 463–93.
- Wehrspann J. 1998. New traits of seed buying. Farm Indus News 31(10): 10.
- White CL, Tabe LM, Dove H, Hamblin J, Young P, Phillips N, Taylor R, Gulati S, Ashes J, Higgins TJV. 2001. Increased efficiency of wool growth and live weight gain in Merino sheep fed transgenic lupin seed containing sunflower albumin. J Sci Food Agric 81: 147–54. Direct Link: LINK
- WHO. 1999. Nutrition Essentials: A Guide for Program Managers. USAID/UNICEF/WHO, Rome, Italy . LINK
- Wieder T, Prokop A, Bagci B, Essmann F, Bernicke D, Schulze-Osthoff K, Dorken B, Schmalz HG, Daniel PT, Henze G. 2001. Piceatannol, a hydroxylated analog of the chemopreventive agent resveratrol, is a potent inducer of apoptosis in the lymphoma cell line BJAB and in primary, leukemic lymphoblasts. Leukemia 15: 1735–42. LINK
- Wigmore SJ, Ross JA, Falconer JS, Plester CE, Tisdale MJ, Carter DC, Fearon KC. 1996. The effect of polyunsaturated fatty acids on the progress of cachexia in patients with pancreatic cancer. Nutrition 12: S27–30. LINK
- Wong NC. 2001. The beneficial effects of plant sterols on serum cholesterol. Can J Cardiol 17: 715–21. LINK
- Yang SH, Moran DL, Jia HW, Bicar EH, Lee M, Scott MP. 2002. Expression of a synthetic porcine alpha-lactalbumin gene in the kernels of transgenic maize. Transgen Res 11: 11–20. LINK
- Yehuda S, Rabinovtz S, Carasso RL, Mostofsky DI. 1996. Essential fatty acids preparation (SR-3) improves Alzheimer’s patients quality of life. Int J Neurosci 87: 141–9. LINK
- Yuan L, Knauf VC. 1997. Modification of plant components. Curr Opin Biotechnol 8: 227–33. LINK
- Ye X, Al-Babili S, Klöti A, Zhang J, Lucca P, Beyer P, Potrykus I. 2000. Engineering the provitamin A (beta-carotene) biosynthetic pathway into (carotenoid-free) rice endosperm. Science 287(5451): 303–5. LINK
- Yue P, Waring S. 1998. Resistant starch in food applications. Cereal Foods World 43: 690–5. LINK
Chapter 3: Safety Assessment of Nutritionally Improved Foods and Feeds Developed through the Application of Modern Biotechnology
- Anderson SA, editor. 1986. Guidelines for use of dietary intake data. U.S. Food and Drug Administration (FDA), Center for Food Safety and Applied Nutrition, Federation of American Societies for Experimental Biology, Life Sciences Research Office (LSRO), Washington, D.C., Bethesda, MD. ; PB87–210886; FDA 223-84-2059.
- ANZFA. 2001. Information for applicants: amending Standard A18/Standard 1.5.2-Food Produced Using Gene Technology. Canberra, Australia: Australia and New Zealand Food Authority.
- Astwood JD, Leach JN, Fuchs RL. 1996. Stability of food allergens to digestion in vitro. Nat Biotechnol 14: 1269–73. LINK
- Aulrich K, Bohme H, Daenicke R, Halle I, Flachowsky G. 2001. Genetically modified feeds in animal nutrition. 1st Communication: Bacillus thuringiensis (Bt) corn in poultry, pig and ruminant nutrition. Arch Tierernaehr 54: 183–95. LINK
- Aumaitre A, Aulrich K, Chesson A, Flachowsky G, Piva G. 2002. New feeds from genetically modified plants: substantial equivalence, nutritional equivalence, digestibility, and safety for animals in the food chain. Livest Prod Sci 74: 223–38. LINK
- Betz FS, Hammond BG, Fuchs RL. 2000. Safety and advantages of Bacillus thuringiensis-protected plants to control insect pests. Regul Toxicol Pharmacol 33: 1. LINK
- Bohme H, Aulrich K, Daenicke R, Flachowsky G. 2001. Genetically modified feeds in animal nutrition. 2nd Communication: Glufosinate tolerant sugar beets (roots and silage) and maize grains for ruminants and pigs. Arch Tierernaehr 54: 197–207. LINK
- Brake J, Vlachos D. 1998. Evaluation of transgenic event 176 “Bt” corn in broiler chickens. Poult Sci 77: 648–53. LINK
- Burks AW, Fuchs RL. 1995. Assessment of the endogenous allergens in glyphosate-tolerant and commercial soybean varieties. J Allergy Clin Immunol 96: 1008–10. LINK
- CAST. 2001. Evaluation of the U.S. Regulatory Process for Crops Developed through Biotechnology. AbramsonSH, DyerWE, FaustMA, HarlanderSK, HefleSL, MunroIC, RiceME, Task Force. Issue Paper, Nr 19. Ames, Iowa: Council for Agricultural Science and Technology.
- CFSAN/FDA. 2002. List of Completed Consultations on Bioengineered Foods. Washington, D.C.: Center for Food Safety and Applied Nutrition, US Food and Drug Administration. Available from: LINK. Accessed 2003 Oct 24.
- Chen S, Huang J, Zhou B, Ni W, Zhang Z, Shen X, Xu Y, Gu L, Li S. 1996. A safety assessment of feeding rats and quails with cotton-seed meal from Bt-transgenic cotton plants. Jiangsu J Agric Sci 12(2): 17–22.
- Chesson A. 2001. Assessing the safety of GM food crops. In: HesterRE, HarrisonRM, editor. Food safety and food quality. Issues Environ Sci Technol 15: 1–24. LINK
- Clark JH, Ipharraguerre IR. 2001. Livestock performance: Feeding biotech crops. J Dairy Sci 84(E. Suppl.): E9–18. LINK
- Codex. 1987. Guidelines on minimum sample sizes for agricultural commodities from supervised field trials for residue analysis (ALINORM 87/24A1987). LINK
- Codex. 2002. Report of the third session of the Codex Ad Hoc Intergovernmental Task Force on foods derived from biotechnology (ALINORM 03/34). March 4–8 2002. Yokohama, Japan. LINK
- Cockburn A. 2002. Assuring the safety of genetically modified (GM) foods: the importance of an holistic, integrative approach. J Biotechnol 98: 79–106. LINK
- Cromwell GL, Lindemann MD, Randolph JH, Parker GR, Coffey RD, Laurent KM, Armstrong CL, Mikel WM, Stanisiewski EP, Hartnell GF. 2002. Soybean meal from roundup or conventional soybeans in diets for growing-finishing swine. J Anim Sci 80: 708–15. LINK
- DEFRA. 2001. Guidance on principles of best practice in the design of genetically modified plants. London, U.K.: Dept. for Environment, Food and Rural Affairs. Available from: LINK. Accessed 2003 Oct 2.
- EEC. 2001. Directive 2001/18/C of he European Parliament and of the Council of 12 March 2001 on the deliberate release into the environment of genetically modified organisms and repealing Council Directive 90/220/EEC).
- EC. 2003. Guidance document for the risk assessment of genetically modified plants and derived food and feed, health and consumer protection. Directorate-General, European Commission. Available from: LINK Accessed 2003 Oct 2. LINK
- Edwards HM, Douglas MW, Parsons CM, Baker DH. 2000. Protein and energy evaluation of soybean meals processed from genetically modified high-protein soybeans. Poult Sci 79: 525–7. LINK
- Ensminger ME, Oldfield JE, Heinemann WW. 1990. Feeds and nutrition. 2nd ed. Clovis, Calif.: Ensminger Publ. Co.
- EPA. 1996. Pesticides and Toxic Substances (7101) EPA 712-C-96-183 August 1996: Residue Chemistry Test Guidelines OPPTS 860. 1500: Crop Field Trials. Washington, D.C.: U.S. EPA.
- EPA. 2000. Data Evaluation Report: Safety Assessment of Starlinkj Genetically Modified Corn Containing the Truncated Bt Insecticidal Protein Cry9C for Human Food Use. MRID 44714001. Arlington Va.: Environmental Protection Agency, Office of Pesticide Programs. Available from: LINK. Accessed 2003 Jul 1.
- Ewen SWB, Pusztai A. 1999. Effect of diet containing genetically modified potatoes expressing Galanthus nivalis lectin on rat small intestine. Lancet 354: 1353–4. LINK
- FAO/WHO. 1996. Biotechnology and food safety. Report of a Joint FAO/WHO Consultation, Sep 30-Oct 4 1996. Rome, Italy: Food and Agriculture Organization of the United Nations/World Health Organization. LINK
- FAO/WHO. 2000. Safety aspects of genetically modified foods of plant origin. Joint FAO/WHO Expert Consultation on Foods Derived From Biotechnology Consultations and Workshops. WHO/SDE/FOS/00.6 (English); 29 May-2 Jun 2000. Geneva, Switzerland: World Health Organization/Food and Agriculture Organization of the United Nations. LINK
- FAO/WHO. 2001. Safety Assessment of Foods Derived From Genetically Modified Microorganisms. Report of a Joint FAO/WHO Expert Consultation on Foods Derived from Biotechnology; 24-28 Sept 2001. Geneva, Switzerland: World Health Organization/Food and Agriculture Organization of the United Nations. Available from: LINK Accessed 2003 Jul 16. LINK
- Fares NH, El Sayed AK. 1998. Fine structural changes in the ileum of mice fed on delta-endotoxin-treated potatoes and transgenic potatoes. Nat Toxins 6: 219–33. LINK
- Hammond BG, Vicini JL, Hartnell GF, Naylor MW, Knight CD, Robinson EH, Fuchs RL, Padgette SR. 1996. The feeding value of soybeans fed to rats, chickens, catfish and dairy cattle is not altered by genetic incorporation of glyphosate tolerance. J Nutr 126: 717–27. LINK
- Hashimoto W, Momma K, Katsube T, Ohkawa Y, Ishige T, Kito M, Utsumi S, Murata K. 1999a. Safety assessment of genetically engineered potatoes with designed soybean glycinin: compositional analyses of the potato tubers and digestibility of the newly expressed protein in transgenic potatoes. J Sci Food Agric 79: 1607–12. LINK
- Hashimoto W, Momma K, Yoon H-J, Ozawa S, Ohkawa Y, Ishige T, Kito M, Utsumi S, Murata K. 1999b. Safety assessment of transgenic potatoes with soybean glycinin by feeding studies in rats. Biosci Biotechnol Biochem 63: 1942–6. LINK
- Hattan D. 1996. Evaluation of toxicological studies on Flavr Savr tomato. In: Food safety evaluation. Paris, France: Organization for Economic Co-operation and Development. p 58–60.
- IFBC. 1990. Biotechnologies and food: Assuring the safety of foods produced by genetic modification. San Diego, Calif.: International Food Biotechnology Council, Academic Press.
- ILSI. 2003. ILSI crop composition database. Washington, D.C.: International Life Sciences Institute. Available from: LINK. Accessed 2003 Jun 25.
- ILSI. 2003. Best practices for the conduct of animal studies to evaluate crops genetically modified for input traits. Washington, D.C.: International Life Sciences Institute. LINK
- Jonas DA, Elmadfa I, Engel K-H, Heller KJ, Kozianowski G, König A, Müller D, Narbonne JF, Wackernagel W, Kleiner J. 2001. Safety considerations of DNA in food. Ann Nutr Metab 45: 235–54. LINK
- Kaniewski WK, Thomas PE. 1999. Field testing for virus resistance and agronomic performance in transgenic plants. Mol Biotechnol 12: 101–15. LINK
- Kessler DA, Taylor MR, Maryanski JH, Flamm EL, Kahl LS. 1992. The safety of foods developed by biotechnology. Science 256: 1747–9. LINK
- Kroes R, Müller D, Lambe J, Löwik MRH, Van Klaveren J, Kleiner J, Massey R, Mayer S, Urieta I, Verger P, Visconti A. 2002. Assessment of intake from the diet. Food Chem Toxicol 40: 327–85. LINK
- Kuiper HA, Kleter GA, Noteborn HPJM, Kok EJ. 2001. Assessment of the food safety issues related to genetically modified foods. Plant J 27: 503–28. LINK
- Lauer BH, Kirkpatrick DC. 1991. Food additive intake: Estimated versus actual. In: MacdonaldI, editor. Monitoring dietary intakes. ILSI Monographs. New York, N.Y.: Springer-Verlag. p 170–82.
- Löwik MRH. 1996. Possible use of food consumption surveys to estimate exposure to additives. Food Addit Contam 13: 427–41. LINK
- LSRO. 1998. Alternative and traditional models for safety evaluation of food ingredients. Raiten DJ editor. Bethesda, Md.: Life Sciences Research Office, American Society for Nutritional Sciences. Prepared for Center for Food Safety and Applied Nutrition, Food and Drug Administration, Dept. of Health and Human Services, Washington, D.C.
- Madans JH, Sondik EJ, Johnson CL. 2003. Future directions for what we eat in America-NHANES: The integrated CSFII-NHANES. J Nutr 133: 575–635. LINK
- Martens MA. 2000. Safety evaluation of genetically modified foods. Int Arch Occup Environ Health 73(Suppl): S14–8. LINK
- MacKenzie DJ. 2000. International comparison of regulatory frameworks for food products of biotechnology. Paper prepared for the Canadian Biotechnology Advisory Committee Project Steering Committee on the Regulation of Genetically Modified Foods. December 2000. Available from: cbac-cccb.ca. Accessed 2003 Oct 2.
- Ministry of Health and Welfare. 2000. Procedures of Application for Safety Assessment of Foods and Food Additives Produced by Recombinant DNA Techniques. Japanese Ministry of Health and Welfare, Announcement Nr 233, May 1 2000.
- Momma K, Hashimoto W, Yoon HJ, Ozawa S, Fukuda Y, Kawai S, Takaiwa F, Utsumi S, Murata K. 2000. Safety assessment of rice genetically modified with soybean glycinin by feeding studies on rats. Biosci Biotechnol Biochem 64: 1881–6. LINK
- Munro IC, McGirr LG, Nestmann ER, Kille JW. 1996a. Alternative approaches to the safety assessment of macronutrient substitutes. Regul Toxicol Pharmacol 23: S6–14. LINK
- Munro IC, Ford RA, Kennepohl E, Sprenger JG. 1996b. Correlation of structural class with no-observed-effect levels: A proposal for establishing a threshold of concern. Food Chem Toxicol 34: 829–67. LINK
- Nair RS, Fuchs RL, Schuette SA. 2002. Current methods for assessing safety of genetically modified crops as exemplified by data on Roundup Ready soybeans. Toxicol Pathol 30: 117–25. LINK
- NAS. 2000a. Dietary reference intakes. Applications in dietary assessments. Food and Nutrition Board, Institute of Medicine. Washington, D.C.: National Academy Press. LINK
- NAS. 2000b. Genetically modified pest-protected plants. Committee on Genetically Modified Pest-Protected Plants. Washington, D.C.: National Research Council, National Academy Press. LINK
- Nordlee JA, Taylor SL, Townsend JA, Thomas LA, Bush RK. 1996. Identification of a Brazil-nut allergen in transgenic soybeans. N Engl J Med 334: 688–92. LINK
- Noteborn HPJM, Bienenmann-Ploum ME, Van Den Berg JHJ, Alink GM, Zolla L, Rey-naerts A, Pensa M, Kuiper HA. 1995. Safety assessment of the Bacillus thuring-iensis insecticidal crystal protein CRYIA(b) expressed in transgenic tomatoes. In: EngelKH, TakeokaGR, TeranishiR, editor. Genetically Modified Foods – Safety Aspects. ACS Symposium Series 605. Washington, D.C.: American Chemical Society. p 134–47. LINK
- OECD. 1993. Safety evaluation of foods derived by modern biotechnology: Concepts and principles. Paris, France: Organization for Economic Co-operation and Development. LINK
- OECD. 1998. Report of the OECD workshop on the toxicological and nutritional testing of novel foods. Paris, France: Organization for Economic Co-operation and Development. LINK
- OECD. 2000. Report of the OECD task force for the safety of novel foods and feeds. Okinawa, Japan: Organization for Economic Co-operation and Development. LINK
- OECD. 2002. Report of the OECD workshop on nutritional assessment of novel foods and feeds. 5–7 February 2001. Ottawa, Canada. Paris, France: Organization for Economic Co-operation and Development. LINK
- Olkowski AA, Classen HL. 1995. Sudden death syndrome in broiler chickens: a review. Poult Avian Biol Rev 6: 95–105.
- Robinson FE, Wilson JL, Yu MW, Fasenko GM, Hardin RT. 1993. The relationship between body weight and reproductive efficiency in meat-type chickens. Poult Sci 72: 912–22. LINK
- Rogan GJ, Bookout JT, Duncan DR, Fuchs RL, Lavrik PB, Love SL, Mueth M, Olson T, Owens ED, Raymond PJ, Zalewski J. 2000. Compositional analysis of tubers from insect and virus resistant potato plants. J Agric Food Chem 45: 5936–45. LINK
- Shewmaker CK, Sheehy JA, Daley M, Colburn S, Yang Ke D. 1999. Seed-specific overexpression of phytoene synthase: increase in carotenoids and other metabolic effects. Plant J 20: 401–12. LINK
- Sidhu RS, Hammond BG, Fuchs RL, Mutz JN, Holden LR, George B, Olson T. 2000. Glyphosate-tolerant corn: The composition and feeding value of grain from glyphosate-tolerant corn is equivalent to that of conventional corn (Zea mays L.). J Agric Food Chem 48: 2305–12. LINK
- Taylor NB, Fuchs RL, MacDonald J, Shariff AR, Padgette SR. 1999. Compositional analysis of glyphosate-tolerant soybeans treated with glyphosate. J Agric Food Chem 47: 4469–73. LINK
- Teshima R, Akiyama H, Okunuki H, Sakushima JI, Goda Y, Onodera H, Sawada JI, Toyoda M. 2000. Effect of GM and Non-GM soybeans on the immune system of BN rats and B10A mice. J Food Hyg Soc Jpn 41: 188–93. LINK
- Teshima R, Watanabe T, Okunuki H, Isuzugawa K, Akiyama H, Onodera H, Imai T, Toyoda M, Sawada J. 2002. Effect of subchronic feeding of genetically modified corn (CBH351) on immune system in BN rats and B10A mice. J Food Hyg Soc Jpn 43: 273–9. LINK
- Tutel’yan VA, Kravchenko LV, Lashneva NV, Avren’eva LI, Guseva GV, Sorokina YE, Chernysheva ON. 1999. Medical-biological evaluation of the safety of protein concentrate obtained from genetically modified soybean. Biochemical investigation. Vopr Pitan 68(5–6): 9–12. LINK
- Wang Y, Lai W, Chen J, Mei S, Fu Y, Hu X, Zhang W. 2000. Toxicity of anti-herbicide gene (BAR) transgenic rice. Wei Sheng Yanjiu 29(3): 141–2. LINK
- Watson SA. 1987. Structure and composition. In: Corn: Watson SA, Ransted PE editors. Chemistry and technology. St. Paul, Minn.: American Association of Cereal Chemists. p 53–82.
- WHO. 1987. Principles for the safety assessment of food additives and contaminants in food. Environmental Health Criteria, Nr 70. Geneva, Switzerland: International Program on Chemical Safety, World Health Organization.
Chapter 4: Nutritional Assessment Process for Nutritionally Improved Food Crops
- Abia R, Pacheco YM, Perona JS, Montero E, Muriana FJG, Ruiz-Gutierrez V. 2001. The metabolic availability of dietary triacylglycerols from two high oleic oils during the postprandial period does not depend on the amount of oleic acid ingested by healthy men. J Nutr 131: 59–65. LINK
- ACNFP. 1997. Annual Report 1997. Advisory Committee on Novel Foods and Processes, Food Standards Agency, London, U.K. Available from: LINK. Accessed 2003 June 25.
- Astwood J, Fuchs R. 2001. Status and safety of biotech crops. ACS Symposium Series 774: Agrochemical Discovery, Insect, Weed and Fungal Control. Ch 14. ACS. p 152–64.
- Bockisch M. 1998. Fats and oils handbook (Nahrungsfette und Ole). Champaign, Ill.: AOCS Press. 848 p.
- Broun P, Gettner S, Sommerville C. 1999. Genetic engineering of plant lipids. Annu Rev Nutr 19: 197–216. LINK
- Canola Council of Canada. 2001. Background of Canola varieties. Available from: LINK. Accessed 2003 May 2.
- CDC. 2002. Centers for Disease Control and Prevention, National Center for Health Statistics, Hyattsville, MD . Available from: LINK. Accessed 2002 May 2.
- CFIA. 2001. Decision Document 2001–34: Determination of the safety of optimum quality grains L.L.C.’s high oleic soybean (Glycine max) lines G94–1, G94–19, and G–168 Derived from Transformation Event Line 260–05. Canada Food Inspection Agency. Available from: LINK. Accessed 2002 May 2.
- Córdova H. 2000. Quality protein maize: Improved nutrition and livelihoods for the Poor. In: Maize research highlights 1999–2000. Mexico City, Mexico: CIMMYT. p 27–31. Available from: LINK. Accessed 2003 November 3.
- Cromwell GL, Pickett RA, Beeson WM. 1967. Nutritional value of opaque-2 corn for swine. J Anim Sci 26: 1325–31. LINK
- DellaPenna D. 2001 Plant metabolic engineering. Plant Physiol 125: 160–3. LINK
- FAO. 2002. Food and Agriculture Organization, Nutrition Country Profiles. Rome, Italy: FAO. Available from: LINK. Accessed 2003 Jun 25.
- FDA. 1998. Food and Drug Administration Agency Response Letter GRAS Notice Nr GRN 000002. Available from: LINK. Accessed 2002 May 4.
- Fromm M, Stark D, Austin G, Perlak F. 1993. Improved agronomic and quality traits. In: Transgenic crops: Recent advances. Philos Trans R Soc Lond B Sci 339: 233–7. LINK
- FSANZ. 2001. Draft Risk Analysis Report. Application A387 – Food derived from high oleic acid soybean lines G94–1, G94–19 and G168. Australia New Zealand Food Authority, Canberra and Wellington . Available from: LINK. Accessed 2003 May 3.
- Health Canada. 1999. High lauric acid canola lines 23–198, 23–18–17. Available from: LINK. Accessed 2003 May 2.
- Health Canada. 2000. High Oleic Soybean Lines G94–1, G94–19, and G168. Novel food information-Food biotechnology. Food Directorate, Health Products and Food Branch. October 2000. Available from: LINK. Accessed 2002 May 4.
- Health Canada. 2001. Low linolenic soybean (OT96–15). Novel food information. Food Directorate, Health Products and Food Branch. April 2001. Available from: LINK. Accessed 2002 May 2.
- ILSI. 1995. The safety assessment of novel foods. Guidelines prepared by the ILSI Europe Novel Food Task Force. Brussels, Belgium: International Life Sciences Institute.
- ILSI. 2003. Crop Composition Database, Washington, D.C.: International Life Sciences Institute. Available from: LINK. Accessed 2003 Jun 25.
- IOM Institute of Medicine. 1989. Recommended dietary allowances. 10th Ed. Washington, D.C.: National Academy Press. 284 p. LINK
- IOM Institute of Medicine. 2002. Dietary reference intakes for energy, carbohydrates, fiber, fat, protein and amino acids (Macronutrients). Washington, D.C.: National Academy Press. 936 p. LINK
- Mertz ET, Bates LS, Nelson OE. 1964. Mutant gene that changes protein composition and increases lysine content of maize endosperm. Science 145: 279–80. LINK
- OECD. 2002. Consensus document on compositional considerations for new varieties of maize (Zea mays): key food and feed nutrients, anti-nutrients and secondary plant metabolites. Paris, France: Organization for Economic Co-operation and Development. LINK
- Oubina P, Sanchez-Muniz FJ, Rodenas S, Cuesta C. 2001. Eicosanoid production, thrombogenic ratio, and serum and LDL peroxides in normo- and hypercholester-olaemic post-menopausal women consuming two oleic acid-rich diets with different content of minor components. Br J Nutr 85: 41–7. LINK
- Pacheco YM, Abia R, Perona JS, Reina M, Ruiz-Gutierrez V, Montero E, Muriana FJG. 2001. Triacylglycerol-rich lipoproteins interact with human vascular cells in a lipid-dependent fashion. J.Agric Food Chem 49: 5653–61. LINK
- Roller S, Harlander S. 1998. Modern food biotechnology: overview of key issues. In: RollerS, HarlanderS, editor. Genetic Modification in the Food Industry. A Strategy for Food Quality Improvement. London, U.K.: Blackie Academic and Professional. LINK
- Ruiz-Gutierrez V, Muriana FJG, Guerrero A, Villar J. 1997. Olive oil and high-oleic sunflower oil on human plasma and erythrocyte membrane lipids. Nutr Res 17: 1391–9. LINK
- Simopoulos AP. 2001. The Mediterranean diets: what is so special about the diet of Greece. J Nutr 131: 3065S–73S. LINK
- Truswell AS, Choudhury N. 1998. Monounsaturated oils do not all have the same effect on plasma cholesterol. Eur J Clin Nutr 52: 312–5. LINK
- USDA. 2002a. National Nutrient Database for Standard Reference Release 15. Available from: LINK. Accessed 2003 Jun 25.
- USDA. 2002b. Data Tables. Food Survey Research Group, Beltsville, MD . Available from: LINK. Accessed 2002 May 4.
- Vasal SK. 1994. High quality protein corn. In: Hallauer AR, editor. Specialty Corns. Boca Raton, Fla.: CRC Press. p 79–121.
- WHO. 2002. Nutrition Data Banks. Global Database on National Nutrition Policies and Programs. World Health Organization, Geneva, Switzerland . Available from: LINK. Accessed 2002 May 4.
Chapter 5: Nutritional Assessment of Animal Feeds Developed through the Application of Modern Biotechnology
- Aumaitre A, Aulrich K, Chesson A, Flachowsky G, Piva G. 2002. New feeds from genetically modified plants: Substantial equivalence, nutritional equivalence, digestibility, and safety for animals in the food chain. Livest Prod Sci 74: 223–38. LINK
- Bletsos E, Goulas C. 1999. Mass selection for improvement of grain yield and protein in a maize population. Crop Sci 39: 1302–5. LINK
- Chesson A. 2001. Assessing the safety of GM food crops. Reprinted from: HesterRE, HarrisonRM, editor. Food Safety and Food Quality. Issues Environ Sci Technol 15: 1–24. LINK
- Clark JH, Ipharraguerre IR. 2001. Livestock performance: Feeding biotech crops. J Dairy Sci 84(E. Suppl.): E9–18. LINK
- Cockburn A. 2002. Assuring the safety of genetically modified (GM) foods: the importance of an holistic, integrative approach. J Biotechnol 98: 79–106. LINK
- FAO. 2002. FAOSTAT Agriculture Data. Available from: LINK. Accessed 2003 Jul 14.
- Flachowsky G, Aulrich K. 2001. Nutritional assessment of feeds from genetically modified organisms. J Anim Feed Sci 10(Suppl 1): 181–94.
- ILSI. 2003. Best practices for the conduct of animal studies to evaluate crops genetically modified for input traits. Washington, D.C.: International Life Sciences Institute. p 1–70. LINK
- ILSI. 2003. Crop composition database. Available from: LINK. Accessed 2003 Jul 14.
- James C. 2003. Preview: Global status of commercialized transgenic crops: 2003. ISAAA Briefs Nr 30. Ithaca, N.Y.: ISAAA. p 1–25. LINK
- Kleter GA, Noordam MY, Kok EJ, Kuiper HA. 2001. New developments in crop plant biotechnology and their possible implications for food product safety. Report 2000.004. Wageningen, The Netherlands: State Institute for Quality Control of Agricultural Products. Available from: LINK. Accessed 2003 Jul 16.
- Kuiper HA, Kleter GA, Noteborn HPJM, Kok EJ. 2001. Assessment of the food safety issues related to genetically modified foods. Plant J 27: 503–28. LINK
- Mieviæ D, Alexander DE. 1989. Twenty-four cycles of phenotypic recurrent selection for percent oil in maize 1. Per se and test-cross performance. Crop Sci 29: 320–4. LINK
- Oba M, Allen MS. 2000. Effects of brown midrib 3 mutation in corn silage on productivity of dairy cows fed two concentrations of dietary neutral detergent fiber: 3. Digestibility and microbial efficiency. J Dairy Sci 83: 1350–8. LINK
- OECD. 2001a. Series on the safety of novel foods and feeds Nr 1. Consensus document on key nutrients and key toxicants in low erucic acid rapeseed (canola). Paris, France: Organization for Economic Co-operation and Development. LINK
- OECD. 2001b. Series on the safety of novel foods and feeds Nr 2. Consensus document on compositional considerations for new varieties of soybean: key food and feed nutrients and anti-nutrients. Paris, France: Organization for Economic Co-operation and Development. LINK
- OECD. 2002a. Series on the safety of novel foods and feeds Nr 3. Consensus document on compositional considerations for new varieties of sugar beet: key food and feed nutrients and anti-nutrients. Paris, France: Organization for Economic Co-operation and Development.
- OECD. 2002b. Series on the safety of novel foods and feeds Nr 4. Consensus document on compositional considerations for new varieties of potatoes: key food and feed nutrients and anti-nutrients and toxicants. Paris, France: Organization for Economic Co-operation and Development. LINK
- OECD. 2002c. Series on the safety of novel foods and feeds Nr 5. Consensus document on compositional considerations for new varieties of maize (Zea mays): key food and feed nutrients and anti-nutrients and secondary metabolities. Paris, France: Organization for Economic Co-operation and Development. LINK
- OECD. 2002d. Report of the Workshop on nutritional assessment of novel foods and feeds; 5–7 February 2001; Ottawa, Canada. Paris, France: Organization for Economic Co-operation and Development.
- OECD. 2003. Series on the safety of novel foods and feeds Nr 9. Considerations for the safety assessment of animal feedstuffs derived from genetically modified plants. Paris, France: Organization for Economic Co-operation and Development. LINK
- Ridley WP, Sidhu RS, Pyla PD, Nemeth MA, Breeze ML, Astwood JD. 2002. Comparison of the nutritional profile of glyphosate-tolerant corn event NK603 with that of conventional corn (Zea mays L.). J Agric Food Chem 50: 7235–43. LINK
- Royal Society. 2002. Genetically modified plants for food use and human health – an update. Policy Document 4/02. Available from: LINK. Accessed 2003 Jul 16.
- Sidhu RS, Hammond BC, Fuchs RL. 2000. Glyphosate-tolerant corn: the composition and feeding value of grain from glyphosate-tolerant corn is equivalent to that of conventional corn (Zea mays L.). J Agric Food Chem 48: 2305–12. LINK
- Soy Stats. 2001. Prepared by the American Soybean Association, St. Louis, MO. Available from: LINK. Accessed 2003 Sep 29.
Chapter 6: The Role of Analytical Techniques in Identifying Unintended Effects in Crops Developed through the Application of Modern Biotechnology
- Andersen JS, Mann M. 2000. Functional genomics by mass spectrometry. FEBS Lett 480: 25–31. LINK
- Beier RC. 1990. Natural pesticides and bioactive components in food. Rev Environ Contam Toxicol 113: 47–137. LINK
- Beranova-Giorgianni S. 2003. Proteome analysis by two-dimensional gel electro-phoresis and mass spectrometry: strengths and limitations. Trends Anal Chem 22: 273–81. LINK
- Carvalho HG, Lopes-Cardoso IA, Lima LM, Melo PM, Cullimore JV. 2003. Nodule-specific modulation of glutamine synthetase in transgenic Medicago truncatula leads to inverse alterations in asparagine synthetase expression. Plant Physiol 133: 243–52. LINK
- Cellini F, Chesson A, Colquhoun I, Constable A, Davies HV, Engel KH, Gatehouse AMR, Kärenlampi S, Kok EJ, Leguay JJ, Lehesranta S, Noteborn HPJM, Pedersen J, Smith M. 2004. Unintended effects and their detection in genetically modified crops. Food Chem Toxicol LINK
- Chen F, Duran A, Blount JA, Sumner LW, Dixon RA. 2003. Profiling phenolic metabolites in transgenic alfalfa modified in lignin biosynthesis. Phytochemistry 64: 1013–21. LINK
- Coulston F, Kolbye AC. 1990. Biotechnologies and food: assuring the safety of foods produced by genetic modification. Regul Toxicol Pharmacol 12: S1–196.
- Datta K, Datta SK. 2002. Plant transformation. In: GilmartinPM, BowlerC, editor. Molecular plant biology; A practical approach, Vol. 1. Oxford, U.K.: Oxford Univ. Press. p 13–33.
- Delhaize E, Hebb DM, Richards KD, Lin JM, Ryan PR, Gardner RC. 1999. Cloning and expression of a wheat (Triticum aestivum) phosphatidylserine synthase cDNA. Overexpression in plants alters the composition of phospholipids. J Biol Chem 274: 7082–8. LINK
- Dueck TA, Van Der Werf A, Lotz LAP, Jordi W. 1998. Methodological Approach to a Risk Analysis for Polygene – Genetically Modified Plants (GMPs): A Mechanistic Study (AB nota 50). Wageningen, Netherlands: Research Institute for Agrobiology and Soil Fertility (AB-DLO). 46 p.
- Engel KH, Gerstner G, Ross A. 1998. Investigation of glycoalkaloids in potatoes as example for the principle of substantial equivalence. In: Novel Food Regulation in the EU – Integrity of the Process of Safety Evaluation. Federal Institute of Consumer Health Protection and Veterinary Medicine, Berlin, Germany . p 197–209.
- Fiehn O, Kopka J, Tretheway N, Willmitzer L. 2000. Identification of uncommon plant metabolites based on calculation of elemental compositions using gas chromatography and quadrupole mass spectrometry. Anal Chem 72: 3573–80. LINK
- Fraser PD, Pinto MES, Holloway DE, Bramley PM. 2000. Application of high-performance liquid chromatography with photodiode array detection to the metabolic profiling of plant isoprenoids. Plant J 24: 551–8. LINK
- Frenzel T, Miller A, Engel KH. 2002. Metabolite profiling – a fractionation method for analysis of major and minor compounds in rice grains. Cereal Chem 79: 215–21. LINK
- FSA. 2003. Novel Foods Research, Research Project List – Safety Assessment of Genetically Modified Foods (G02). London, U.K.: U.K. Food Standards Agency. Available from: LINK. Accessed 2003 Oct 1.
- Gheysen G, Villarroel R, Van Montagu M. 1991. Illegitimate recombination in plants: a model for T-DNA integration. Genes Dev 5: 287–97. LINK
- GMOCARE. 2003. GMOCARE, New Methodologies for Assessing the Potential of Unintended Effects in Genetically Modified Food Crops, QLK1-1999–00765. Wageningen, The Netherlands: RIKILT – Institute of Food Safety. Available from: LINK. Accessed 2003 Oct 1.
- Grevelding C, Fantes V, Kemper E, Schell J, Masterson R. 1993. Single-copy T-DNA insertions in Arabidopsis are the predominant form of integration in root-derived transgenics, whereas multiple insertions are found in leaf discs. Plant Mol Biol 23: 847–60. LINK
- Gygi SP, Y Rochon, Franza BR, Aebersold R. 1999. Correlation between protein and mRNA abundance in yeast. Mol Cell Biol 19: 1720–30. LINK
- Han DK, Eng J, Zhou H, Aebersold R. 2001. Quantitative profiling of differentiation-induced microsomal proteins using isotope-coded affinity tags and mass spectrometry. Nat Biotechnol 19: 946–51. LINK
- Harlander SK. 2002. The evolution of modern agriculture and its future with biotechnology. J Am Coll Nutr 21(Suppl. S): 161S–5S. LINK
- Harvey MH, McMillan M, Morgan MR, Chan HW. 1985. Solanidine is present in sera of healthy individuals and in amounts dependent on their dietary potato consumption. Human Toxicol 4: 187–94. LINK
- Hashimoto W, Momma K, Katsube T, Ohkawa Y, Ishige T, Kito M, Utsumi S, Murata K. 1999a. Safety assessment of genetically engineered potatoes with designed soybean glycinin: compositional analyses of the potato tubers and digestibility of the newly expressed protein in transgenic potatoes. J Sci Food Agric 79: 1607–12. 3.0.CO;2-T/abstract”LINK
- Hashimoto W, Momma K, Yoon HJ, Ozawa S, Ohkawa Y, Ishige T, Kito M, Utsumi S, Murata K. 1999b. Safety assessment of transgenic potatoes with soybean glycinin by feeding studies in rats. Biosci Biotechnol Biochem 63: 1942–6. LINK
- Haynes PA, Yates JR III 2000. Proteome profiling-pitfalls and progress. Yeast 17: 81–7. 3.0.CO;2-Z/abstract”LINK
- Heinekamp T, Kuhlmann M, Lenk A, Strathmann A, Droge-Laser W. 2002. The tobacco bZIP transcription factor BZI-1 binds to G-box elements in the promoters of phenylpropanoid pathway genes in vitro, but it is not involved in their regulation in vivo. Mol Genet Genomics 267: 16–26. LINK
- Iglesias VA, Moscone EA, Papp I, Michalowski S, Phelan T, Spiker S, Neuhuber F, Matzke M, Matzke AJM. 1997. Molecular and cytogenetic analyses of stably and unstably expressed transgene loci in tobacco. Plant Cell 9: 1251–64. LINK
- Kinney AJ, Knowlton S. 1998. Designer oils: the high oleic acid soybean. In: RollerS, HarlanderS, editor. Genetic Modification in the Food Industry, A Strategy for Food Improvement. London, U.K.: Blackie. p 193–213.
- Kuiper HA, Kleter GA, Noteborn HPJM, Kok EJ. 2001. Assessment of the food safety issues related to genetically modified foods. Plant J 27: 503–28. Available from: LINK. Accessed 2004 Feb 19. Direct Link: LINK
- Kuiper HA, Kok EJ, Engel KH. 2003. Exploitation of molecular profiling techniques for GM food safety assessment. Curr Opin Biotechnol 14: 238–43. LINK
- Li Y, Kandasamy MK, Meagher RB. 2001. Rapid isolation of monoclonal antibodies. Monitoring enzymes in the phytochelatin synthesis pathway. Plant Physiol 127: 711–9. LINK
- Lommen A, Weseman JM, Smith GO, Noteborn HPJM. 1998. On the detection of environmental effects on complex matrices combining off-line liquid chromatography and H-NMR. Biodegradation 9: 513–25. LINK
- Mertz ET. 1992. Discovery of high lysine, high tryptophan cereals. In: Mertz ET, editor. Quality Protein Maize. St. Paul, Minn.: American Association of Cereal Chemists. p 1–8.
- Moire L, Rezzonico E, Goepfert S, Poirier Y. 2004. Impact of unusual fatty acid synthesis on futile cycling through beta-oxidation and on gene expression in transgenic plants. Plant Physiol 134: 432–42. LINK
- Momma K, Hashimoto W, Ozawa S, Kawai S, Katsube T, Takaiwa F, Kito M, Utsumi S, Murata K. 1999. Quality and safety evaluation of genetically engineered rice with soybean glycinin: analyses of the grain composition and digestibility of glycinin in transgenic rice. Biosci Biotechnol Biochem 63: 314–8. LINK
- Murray F, Llewellyn D, McFadden H, Last D, Dennis ES, Peacock WJ. 1999. Expression of the Talaromyces flavus glucose oxidase gene in cotton and tobacco reduces fungal infection, but is also phytotoxic. Mol Breed 5: 219–32. LINK
- Noteborn HPJM. 1998. Chemical fingerprinting and in vitro toxicological profiling for the safety evaluation of transgenic food crops. In: Report of a Workshop on the Toxicological and Nutritional Testing of Novel Foods. Paris, France: Organization for Economic Co-operation and Development. p 32–3.
- Noteborn HPJM, Lommen A, Weseman JM, Van Der Jagt RCM, Groenendijk FPF. 1998. Chemical fingerprinting and in vitro toxicological profiling for the safety evaluation of transgenic food crops. In: Horning M, editor. Report of the Demonstration Program on Food Safety Evaluation of Genetically Modified Foods as a Basis for Market Introduction. The Hague, Netherlands: Information & Newssupply Dept., Ministry of Economic Affairs. p 51–79.
- Noteborn HPJM, Lommen A, Van der Jagt RC, Weseman JM. 2000. Chemical fingerprinting for the evaluation of unintended secondary metabolic changes in transgenic food crops. J Biotechnol 77: 103–14. LINK
- OECD. 2003. Consensus Documents for the Work on the Safety of Novel Foods and Feeds. Paris, France: Organization for Economic Co-operation and Development. Available from: LINK. Accessed on 2004 Feb 19.
- Pedersen C, Pedersen C, Zimny J, Becker D, Jähne-Gärtner A, Lörz H. 1997. Localization of introduced genes on the chromosomes of transgenic barley, wheat, triticale by fluorescence in situ hybridization. Theor Appl Genet 94: 749–57. LINK
- Roessner U, Wagner C, Kopka J, Tretheway N, Willmitzer L. 2000. Simultaneous analysis of metabolites in potato tuber by gas chromatography-mass spectrometry. Plant J 23: 131–42. Direct Link: LINK
- Sauter H, Lauer M, Fritsch H. 1991. Metabolic profiling of plants – a new diagnostic technique. In: BakerDR, FenyesJG, editor. Synthesis and Chemistry of Agro-chemicals II, ACS Symposium Series 443. Washington, D.C.: American Chemical Society. p 288–99. LINK
- Sawasaki T, Takahashi M, Goshima N, Morikawa H. 1998. Structures of transgene loci in transgenic Arabidopsis plants obtained by particle bombardment: junction regions can bind to nuclear matrices. Gene 218: 27–35. LINK
- Schena M, Shalon D, Davis RW, Brown PO. 1995. Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 270: 467–70. LINK
- Schena M, Shalon D, Heller R, Chai A, Brown PO, Davis RW. 1996. Parallel human genome analysis: Microarray-based expression monitoring of 1000 genes. Proc Nat Acad Sci USA 93: 10614–9. LINK
- Schnable PS, Hsia AP, Nikolau BJ. 1998. Genetic recombination in plants. Curr Opin Plant Biol 1: 123–9. LINK
- Shewmaker CK, Sheely JA, Daley M, Colburn S, Ke DY. 1999. Seed-specific over-expression of phytoene synthase: increase in carotenoids and other metabolic effects. Plant J 22: 401–12. Direct Link: LINK
- Siebert R, Puchta H. 2002. Efficient repair of genomic double-strand breaks by homologous recombination between directly repeated sequences in the plant genome. Plant Cell 14: 1121–31 Accessed 2003 Oct 1. LINK
- Spertini D, Beliveau C, Bellemare G. 1999. Screening of transgenic plants by amplification of unknown genomic DNA flanking T-DNA. Biotechniques 27: 308–14. LINK
- Thomas WTB, Baird E, Fuller JD, Lawrence P, Young GR, Russell J, Ramsay L, Waugh R, Powell W. 1998. Identification of a QTL decreasing yield in barley linked to Mlo powdery mildew resistance. Mol Breed 4: 381–93. LINK
- Turk SCHJ, Smeekens SCM. 1999. Genetic modification of plant carbohydrate metabolism. In: ChopraVL, MalikVS, BhatSR, editor. Applied Plant Biotechnology. Enfield, U.K.: Science Publishers. p 71–100.
- Van Hal NLW, Vorst O, Van Houwelingen AMML, Kok EJ, Peijnenburg A, Aharoni A, Van Tunen AJ, Keijer J. 2000. The application of DNA microarrays in gene expression analysis. J Biotechnol 78: 271–80. LINK
- Villegas E, Vasal SK, Bjarnason M, Mertz ET. 1992. Quality protein maize – what is it and how was it developed. In: MertzET, editor. Quality Protein Maize. St. Paul, Minn.: American Association of Cereal Chemists. p 27–48.
- Ye X, Al-Babili S, Klöti A, Zhang J, Lucca P, Beyer P, Potrykus I. 2000. Engineering the provitamin A (β-carotene) biosynthetic pathway into (carotenoid-free) rice endosperm. Science 287: 303–5. LINK
Chapter 7: Postmarket Monitoring
- Allgood GS, Kuter DJ, Roll KT, Taylor SL, Zorich NL. 2001. Postmarketing surveillance of new food ingredients: Results from the program with the fat replacer Olestra. Regul Toxicol Pharmacol 33: 224–33. LINK
- Borzelleca JF. 1995. Post-marketing surveillance of macronutrient substitutes. Food Technol 49: 107–13. LINK
- Butchko HH, Tschanz C, Kotsonis FN. 1994. Postmarketing surveillance of food additives. Regul Toxicol Pharmacol 20: 105–18. LINK
- Chesson A. 2001. Assessing the safety of GM food crops. Issues in Environmental Science and Technology Nr 15. Cambridge, U.K.: Royal Society of Chemistry. p 1–24.
- Codex 2002. Codex Alimentarius Commission. Report of the third session of the Codex ad hoc intergovernmental task force on foods derived from biotechnology. Yokohama, Japan 4–8 March 2002. Alinorm 03/34. Available from: LINK. Accessed 2003 Jun 24.
- EC. 1997a. European Commission Regulation No. 258/97 of the European Parliament and of the Council of 27 January 1997 concerning novel foods and novel food ingredients. Off J Eur Commun L43: 1–7. Available from: LINK. Accessed 2003 Jun 24.
- EC. 1997b. European Commission Recommendation of 29 July 1997 concerning the scientific aspects and the presentation of information necessary to support applications for the placing on the market of novel foods and novel food ingredients and the preparation of initial assessment reports under Regulation (EC) No 258/97 of the European Parliament and of the Council (Text with EEA relevance) Off J Eur Commun L253: 1–36.
- EC. 2001a. European Commission Directive 2001/18/EC of the European Parliament and of the Council of 12 March 2001 on the deliberate release into the environment of genetically modified organisms and repealing Council Directive 90/220/EEC. Off J Eur Commun L106: 1–39. Available from: LINK. Accessed 2003 Jun 24.
- EC. 2001b. European Commission Proposal for a regulation of the European Parliament and of the Council on genetically modified food and feed. COM/2001/0425; Off J Eur Commun C304 E: 1–64. Available from: LINK. Accessed 2003 Jun 24.
- EC. 2002. European Commission Preliminary guidance document on the information needed for the risk assessment of genetically modified plants and derived food and feed. GM-NF WG/Guide/005. Available from: LINK. Accessed 2003 Jun 24.
- FAO/WHO. 2000. Safety Aspects of Genetically Modified Foods of Plant Origin. Report of a Joint FAO/WHO Expert Consultation on Foods Derived From Biotechnology Consultations and Workshops; May 29-June 2 2000; WHO Headquarters, Geneva, Switzerland . World Health Organization, Food Safety Program/Food and Agriculture Organization of the United Nations. WHO/SDE/FOS/00.6 (English).
- FAO/WHO. 2001. Evaluation of Allergenicity of Genetically Modified Foods. Report of a Joint FAO/WHO Expert Consultation on Allergenicity of Foods Derived from Biotechnology; 22–25 January 2001. Rome, Italy: Food and Agriculture Organization of the United Nations. Available from: LINK. Accessed 2003 June 24.
- FDA. 1992. Statement of Policy: Foods Derived From New Plant Varieties; Notice. Food and Drug Administration. Dept. of Health and Human Services. Federal Register 57: 22984–23002.
- Hill AB. 1965. The environment and disease: association or causation. Proc R Soc Med 58: 295–300. LINK
- Kroes R, Müller D, Lambe J, Löwik MRH, Van Klaveren J, Kleiner J, Massey R, Mayer S, Urieta I, Verger P, Visconti A. 2002. Assessment of intake from the diet. Food Chem Toxicol 40: 327–85. LINK
- Kuiper HA, Kleter GA, Noteborn HPJM, Kok EJ. 2001. Assessment of the food safety issues related to genetically modified foods. Plant J 27: 503–28. LINK
- LSRO. 1998. Life Sciences Research Office. Alternative and Traditional Models for Safety Evaluation of Food Ingredients. RaitenDJ, editor. Bethesda, Md.: Am. Soc. Nutr. Sci.
- Munro IC, McGirr LG, Nestmann ER, Kille JW. 1996. Alternative approaches to the safety assessment of macronutrient substitutes. Regul Toxicol Pharmacol 23: S6–14. LINK
- NRC. 2000. Genetically Modified Pest-Protected Plants. Committee on Genetically Modified Pest-Protected Plants, National Research Council. Washington, D.C.: National Academy Press. LINK
- SCF. 2002. Opinion of the Scientific Committee on Food on a report on Post Launch Monitoring of “yellow fat spreads with added phytosterol esters”. (Expressed on 26 September 2002) Scientific Committee on Food, SCF/CS/NF/DOS/21 ADD 2 Final, 4 October 2002. Available from: LINK. Accessed 2003 Jun 24.
- Schaefer EJ. 2002. Lipoproteins, nutrition and heart disease. Am J Clin Nutr 75: 191–212. LINK
- Slough CL, Miday RK, Zorich NL, Jones JL. 2001. Postmarketing surveillance of new food ingredients: Design and implementation of the program for the fat replacer Olestra. Regul Toxicol Pharmacol 33: 218–23. LINK
- Stave JW. 2002. Protein immunoassay methods for detection of biotech crops: applications, limitations, and practical considerations. J AOAC Int 85: 780–6. LINK
- Taylor SL, Hefle SL. 2002. Genetically engineered foods: implications for food allergy. Curr Opin Allergy Clin Immunol 2: 249–52. LINK
- Taylor SL, Hefle SL, Bindslev-Jensen C, Bock SA, Burks AW, Christie L, Hill DJ, Host A, Hourihane JO, Lack G, Metcalfe DD, Moneret-Vautrin DA, Vadas PA, Rance F, Skrypec DJ, Trautman TA, Malmheden Yman I, Zeiger RS. 2002. Factors affecting the determination of threshold doses for allergenic foods: How much is too much. J Allergy Clin Immunol 109: 24–30. LINK
- Thornquist MD, Kristal AR, Patterson RE, Neuhouser ML, Rock CL, Neumark-Sztain-er D, Cheskin LJ. 2000. Olestra consumption does not predict serum concentrations of carotenoids and fatsoluble vitamins in free-living humans: Early results from the Sentinal site of the Olestra Post-Marketing Surveillance Study. J Nutr 130: 1711–8. LINK
- Van Den Brandt P, Voorrips L, Hertz-Picciotto I, Shuker D, Boeing H, Speijers G, Guittard C, Kleiner J, Knowles M, Wolk A, Goldbohm A. 2002. The contribution of epidemiology. Food Chem Toxicol 40: 387–424. LINK
- WHO. 1987. Principles for the Safety Assessment of Food Additives and Contaminants in Food. International Program on Chemical Safety, Environmental Health Criteria, Nr 70. Geneva, Switzerland: World Health Organization.