Evaluation of Protein Safety in the Context of Agricultural Biotechnology

Delaney B, Astwood JD, Cunny H, Conn RE, Herouet-Guicheney C, MacIntosh S, Meyer LS, Privalle L, Gao Y, Mattsson J, Levine M

Task Force #6

Food and Chemical Toxicology. 2008;46:S71-S97

Published as a supplement in Food and Chemical Toxicology, this unique document brings together a considerable body of information about the science underlying protein safety assessment and puts forth a scientifically based two-tiered, weight-of evidence strategy to assess the safety of novel proteins used in the context of agricultural biotechnology.

Recommendations draw upon knowledge of the biological and chemical characteristics of proteins and testing methods for evaluating potential intrinsic hazards of chemicals. The application of this strategy is presented using examples of transgenic proteins applied for agricultural input and output traits in genetically modified crops along with recommendations for future research considerations related to protein safety assessment.

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