By Invitation Only


Most regulatory systems have developed standard test methods and data requirements for addressing the potential effects on non-target organisms (NTO) resulting from their exposure to genetically engineered plants expressing Bt proteins (insecticidal proteins primarily derived from Bacillus thuringiensis). However, recent developments in multiple technologies have led to the production of GE plants that incorporate pest protection without pesticidal proteins (e.g., using RNAi) or use of proteins that are not functionally related to Bt proteins. Although the overall assessment paradigm for GE plants is robust and can still be used to produce NTO assessments, there are ongoing discussions about the appropriate NTO tests and measurement endpoints for these new technologies. When is it appropriate to conduct sublethal endpoint assessment testing? What types of assays should be employed?

To answer such questions, the Agriculture & Food Systems Institute convened scientists from academia, government, and industry to participate in a workshop on sublethal endpoints in NTO testing for non-Bt GE crops on March 5-6, 2019 in Washington, D.C. The criteria for making decisions regarding sublethal endpoint assessment testing that were developed during the workshop will be valuable in guiding future risk assessments of GE plants where sublethal effects on NTOs might be anticipated.

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